ISSN 1302-6631
 

Original Research (Original Article) 


Bone mineral density in patients treated with antipsychotics

Arzu Cengiz, Vesile Altınyazar, Burcu Gülün Manoğlu, Fatih Vahapoğlu, Oktay Kocabaş, İmran Kurt Ömürlü, Yakup Yürekli.

Abstract
Objective: The aim of this study was to investigate the effect of prolactin levels, duration of disease, accompanying metabolic syndrome, use of mood stabilizer drugs, smoking and exercise on bone mineral density (BMD) in patients treated with antipsychotics. Methods: Fifty-six patients who had been diagnosed with schizophrenia, forty-one patients who had been diagnosed with schizoaffective disorder and thirty three patients who had been diagnosed with bipolar disorders were included the study. BMD was measured at the lumbar spine and femoral sites using dual energy x-ray absorptiometry (DEXA). Arterial blood pressure, waist circumference, fasting glucose, HDL cholesterol and triglyceride levels of the patients were measured for diagnosis of metabolic syndrome. The age, weight, height, smoking habits, regular physical exercise, additional mood stabilizer drugs administered and blood prolactin levels were recorded. Results: Results of 73 patients were osteopenia or osteoporosis. There was no statistically significant relationship between BMD and plasma prolactin level, using additional mood stabilizer drugs, dose of antipsychotic drugs and metabolic syndrome. There was negative correlation between duration of illness, duration of antipsychotic drug use and BMD of the femoral neck. There was negative correlation between duration of smoking and BMD of femoral intertrochanteric region. Lumbar BMD was significantly higher in patients exercising regularly than those of patients without regular physical exercise. Conclusion: Due to a sedantary lifestyle, pro-longed use of antipsychotic drugs and smoking risk of osteoporosis increases in patients with schizophrenia, schizo-affective disorder and bipolar disorder. BMD of these patients should be followed-up with regular intervals. (Ana-tolian Journal of Psychiatry 2019; 20(x):xx-xx)

Key words: Bone density, schizophrenia, bipolar disorders, osteoporosis



Antipsikotiklerle tedavi edilen hastalarda kemik mineral yoğunluğu

Ozet
Amaç: Bu çalışmanın amacı, antipsikotik ile tedavi edilen hastalarda prolaktin düzeyi, hastalık süresi, eşlik eden metabolik sendrom, duygudurum düzenleyici kullanımı, sigara içme ve egzersizin kemik mineral yoğunluğu üzerine etkisini araştırmaktır. Yöntem: Çalışmaya 56 şizofreni hastası, 41 şizoaffektif bozukluk hastası, 33 bipolar bozukluk hastası alınmıştır. Kemik mineral yoğunluğu (KMY) ölçümü lomber vertebra ve femurdan dual enerji X-ray absorp-siyometri (DEXA) kullanılarak ölçüldü. Metabolik sendrom tanısı için hastaların arteriyal kan basıncı, bel çevresi, açlık kan şekeri, HDL kolesterol ve trigliserid düzeyi ölçümleri yapıldı. Yaş, ağırlık, boy, sigara alışkanlığı, düzenli fiziksel egzersiz alışkanlığı, ek duygudurum düzenleyici kullanımı ve kan prolaktin düzeyleri kayıt edildi. Bulgular: Yetmiş üç hastanın sonucu osteopeni veya osteoporoz idi. KMY ile serum prolaktin düzeyi, ek duygudurum düzen-leyici kullanımı, antipsikotik ilaç dozu ve metabolik sendrom arasında istatistiksel olarak anlamlı ilişki yoktu. Hastalık süresi ve antipsikotik ilaç kullanım süresi ile femur boyun KMY arasında negative korelasyon saptandı. Sigara içme süresi ile femur intertorakanterik bölge KMY arasında negatif korelasyon saptandı. Düzenli egzersiz yapan hasta- larda lomber KMY yoğunluğu düzenli egzersiz yapmayanlardan anlamlı olarak yüksekti. Sonuç: Sedanter yaşam tarzı, uzamış antipsikotik ilaç ve sigara içme şizofreni, şizoaffektif bozukluk ve bipolar bozukluk hastalarında osteo-poroz riskini artırmaktadır. Bu hastalarda KMY düzenli aralıklarla izlenmelidir.

Anahtar Kelimeler: Kemik yoğunluğu, şizofreni, bipolar bozukluk, osteoporoz


 
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How to Cite this Article
Pubmed Style

Cengiz A, Altinyazar V, Manoglu BG, Vahapoglu F, Kocabas O, Omurlu IK, Yurekli Y. Bone mineral density in patients treated with antipsychotics. Anadolu Psikiyatri Derg. 2019; 20(2): 182-188. doi:10.5455/apd.1453


Web Style

Cengiz A, Altinyazar V, Manoglu BG, Vahapoglu F, Kocabas O, Omurlu IK, Yurekli Y. Bone mineral density in patients treated with antipsychotics. http://www.anadolupsikiyatri.net/?mno=1453 [Access: June 27, 2019]. doi:10.5455/apd.1453


AMA (American Medical Association) Style

Cengiz A, Altinyazar V, Manoglu BG, Vahapoglu F, Kocabas O, Omurlu IK, Yurekli Y. Bone mineral density in patients treated with antipsychotics. Anadolu Psikiyatri Derg. 2019; 20(2): 182-188. doi:10.5455/apd.1453



Vancouver/ICMJE Style

Cengiz A, Altinyazar V, Manoglu BG, Vahapoglu F, Kocabas O, Omurlu IK, Yurekli Y. Bone mineral density in patients treated with antipsychotics. Anadolu Psikiyatri Derg. (2019), [cited June 27, 2019]; 20(2): 182-188. doi:10.5455/apd.1453



Harvard Style

Cengiz, A., Altinyazar, . V., Manoglu, . B. G., Vahapoglu, . F., Kocabas, . O., Omurlu, . I. K. & Yurekli, . Y. (2019) Bone mineral density in patients treated with antipsychotics. Anadolu Psikiyatri Derg, 20 (2), 182-188. doi:10.5455/apd.1453



Turabian Style

Cengiz, Arzu, Vesile Altinyazar, Burcu Gulun Manoglu, Fatih Vahapoglu, Oktay Kocabas, Imran Kurt Omurlu, and Yakup Yurekli. 2019. Bone mineral density in patients treated with antipsychotics. Anatolian Journal of Psychiatry, 20 (2), 182-188. doi:10.5455/apd.1453



Chicago Style

Cengiz, Arzu, Vesile Altinyazar, Burcu Gulun Manoglu, Fatih Vahapoglu, Oktay Kocabas, Imran Kurt Omurlu, and Yakup Yurekli. "Bone mineral density in patients treated with antipsychotics." Anatolian Journal of Psychiatry 20 (2019), 182-188. doi:10.5455/apd.1453



MLA (The Modern Language Association) Style

Cengiz, Arzu, Vesile Altinyazar, Burcu Gulun Manoglu, Fatih Vahapoglu, Oktay Kocabas, Imran Kurt Omurlu, and Yakup Yurekli. "Bone mineral density in patients treated with antipsychotics." Anatolian Journal of Psychiatry 20.2 (2019), 182-188. Print. doi:10.5455/apd.1453



APA (American Psychological Association) Style

Cengiz, A., Altinyazar, . V., Manoglu, . B. G., Vahapoglu, . F., Kocabas, . O., Omurlu, . I. K. & Yurekli, . Y. (2019) Bone mineral density in patients treated with antipsychotics. Anatolian Journal of Psychiatry, 20 (2), 182-188. doi:10.5455/apd.1453





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