ISSN 1302-6631
 

Original Research (Original Article) 


Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics

Tunay Karlıdere, Özcan Uzun, Adem Balıkcı.

Abstract
Objective: Depression is an important syndrome occurring frequently during the course of schizophrenia. In patients using atypical antipsychotics in the treatment of schizophrenia, depressive symptoms are expected at a lower rate. In this retrospective study, evaluation of depressive symptoms in patients who were monitored for one year with first-episode schizophrenia using atypical or conventional antipsychotic treatment was intended. Methods: The study was carried out by examining the records of 93 patients with first-episode schizophrenia. The data of the Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Hamilton Depression Rating Scale and the Calgary Depression Scale were used for evaluation. Classical antipsychotics (n=21), olanzapine (n=28), risperidone (n=25) or quetiapine (n=19) were found to be used in the treatment of subjects. According to clinical status, the subjects were invited to the controls at intervals not longer than two months. The above scales were applied to subjects at each control to measure the depressive symptoms and to determine the relationship of those with clinical variables. Results: The classic antipsychotic group (57.1%) showed more significantly severe depressive symptoms (HAM-D score≥17) than the atypical antipsychotic group (31.9%). The rate of depression and depressive symptoms were similar among the subjects used atypical antipsychotic agents. Conclusion: Possibly depending on their mechanism of action and the effects on negative symptoms of patients with schizophrenia, the atypical antipsychotic drugs showed lower rate of depression compared to conventional antipsychotics.

Key words: first episode schizophrenia, depression, depressive symptoms, classical antipsychotic, atypical antipsychotic



Tedavi altındaki ilk atak şizofreni olgularında depresif belirtiler: Bir yıllık izlemede klasik ve atipik antipsikotiklerin karşılaştırılması

Ozet
Amaç: Depresyon şizofreninin gidişi sırasında sıklıkla ortaya çıkan önemli bir sendromdur. Şizofreninin tedavisinde atipik antipsikotik kullanan olgularda depresif belirtilerin daha düşük oranda gözlenmesi beklenmektedir. Geriye dönük bu çalışmada, bir yıl süreyle izlenen atipik veya klasik antipsikotik tedavi kullanan ilk atak şizofreni olgularındaki depresif belirtilerin değerlendirilmesi amaçlanmıştır. Yöntem: Çalışma, 93 ilk atak şizofreni olgusunun kayıtlarının incelenmesi ile gerçekleştirilmiştir. Değerlendirme için Kısa Psikiyatrik Derecelendirme Ölçeği, Pozitif Belirtileri Değerlendirme Ölçeği, Negatif Belirtileri Değerlendirme Ölçeği, Hamilton Depresyon Ölçeği, Calgary Depresyon Ölçeği verileri kullanılmıştır. Olguların tedavisinde klasik antipsikotik (s=21), olanzapin (s=28), risperidon (s=25) veya ketiyapin (s=19) kullanıldığı saptanmıştır. Olgular, klinik durumlarına göre iki aydan uzun olmayan aralıklarla kontrollere çağrılmıştır. Depresif belirtilerin ölçülmesi ve bunların klinik değişkenlerle ilişkisinin saptanması için yukarıdaki ölçekler olgulara her kontrolde uygulanmıştır. Bulgular: Klasik antipsikotik grubunda (%57.1) atipik antipsikotik grubuna (%31.9) göre daha fazla anlamlı şiddette depresif belirtiler (HAM-D puanı≥17) saptanmıştır. Depresyon ve depresif belirtiler oranı atipik antipsikotik kullanan olgular arasında benzer bulunmuştur. Tartışma: Olasılıkla etki düzeneklerine ve negatif belirtiler üzerindeki etkilerine bağlı olarak atipik antipsikotik kullanan şizofreni olgularında, klasik antipsikotik kullananlara göre daha düşük oranda depresyon tablosu gelişmektedir.

Anahtar Kelimeler: İlk atak şizofreni, depresyon, depresif belirtiler, klasik antipsikotik, atipik antipsikotik


 
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How to Cite this Article
Pubmed Style

Karlidere T, Uzun O, Balikci A. [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anadolu Psikiyatri Derg. 2015; 16(1): 7-13. Turkish. doi:10.5455/apd.151212


Web Style

Karlidere T, Uzun O, Balikci A. [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. http://www.anadolupsikiyatri.net/?mno=151212 [Access: July 21, 2018]. Turkish. doi:10.5455/apd.151212


AMA (American Medical Association) Style

Karlidere T, Uzun O, Balikci A. [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anadolu Psikiyatri Derg. 2015; 16(1): 7-13. Turkish. doi:10.5455/apd.151212



Vancouver/ICMJE Style

Karlidere T, Uzun O, Balikci A. [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anadolu Psikiyatri Derg. (2015), [cited July 21, 2018]; 16(1): 7-13. Turkish. doi:10.5455/apd.151212



Harvard Style

Karlidere, T., Uzun, O. & Balikci, A. (2015) [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anadolu Psikiyatri Derg, 16 (1), 7-13. Turkish. doi:10.5455/apd.151212



Turabian Style

Karlidere, Tunay, Ozcan Uzun, and Adem Balikci. 2015. [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anatolian Journal of Psychiatry, 16 (1), 7-13. Turkish. doi:10.5455/apd.151212



Chicago Style

Karlidere, Tunay, Ozcan Uzun, and Adem Balikci. "[Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]." Anatolian Journal of Psychiatry 16 (2015), 7-13. Turkish. doi:10.5455/apd.151212



MLA (The Modern Language Association) Style

Karlidere, Tunay, Ozcan Uzun, and Adem Balikci. "[Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]." Anatolian Journal of Psychiatry 16.1 (2015), 7-13. Print.Turkish. doi:10.5455/apd.151212



APA (American Psychological Association) Style

Karlidere, T., Uzun, O. & Balikci, A. (2015) [Depressive symptoms in first episode schizophrenia patients under treatment: one-year follow-up comparison of classical and atypical antipsychotics]. Anatolian Journal of Psychiatry, 16 (1), 7-13. Turkish. doi:10.5455/apd.151212





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