ISSN 1302-6631
 

Original Research (Original Article) 


Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment

Ahmet Tiryaki, Demet Sağlam Aykut, Evrim Özkorumak Karagüzel, Süleyman Caner Karahan.

Abstract
Objective: Function of NO and its intra-system competitive inhibitor of the nitric oxide, asymmetric dimethylarginine (ADMA) has been investigated in mood disorders, schizophrenia, autism, obsessive compulsive disorder and Alzheimer Disorder and significant results were obtained. The mechanism of action in mood stabilizators is still unclear despite many years of studies. The parameters of oxidative stres were shown to decreased upon antimanic treatment in bipolar affective disorder (BAD). The lithium may be suggested to produce neuroprotective effects against oxidative damage by regulatory effects towards various targets. The effects of lithium on nitric oxide synthase were researched in laboratory studies. In this study, two tubes of plasma were taken from the patients for determination of NO and ADMA during manic and euthymic phases. Methods: Seventeen patients who presented to the psychiatry or emergency departments of Farabi Hospital of Karadeniz Technical University and were diagnosed with BAD-I manic episode and followed with lithum were included into the study. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS), Montgomery-Asberg Depression Rating Scale (MADRS), were applied. For determination of NO and ADMA levels, two tubes of plasma were collected during the periods of mania and euthymia in the patient group. Results: The level of ADMA were significantly lower while the level of NO were higher in the posttreatment group than the pretreatment group. Conclusion: In this study, the level of NO were increased, the level of ADMA were dicreased in response to lithium treatment, and the therapeutic effect of lithium may contribute this mechanism.

Key words: bipolar affective disorder-I, nitric oxide (NO), asymmetric dimethylarginine (ADMA), lithium



İki uçlu duygudurum bozukluğunda tedavi öncesi ve tedavi sonrası akut mani dönemlerinde kan nitrik oksit ve asimetrik dimetilarginin düzeylerinin karşılaştırılması

Ozet
Amaç: Nitrik oksitin (NO) ve NO’nun sistem içi baskılayıcısı olan asimetrik dimetilargininin (ADMA) işlevi, duygudurum bozuklukları, şizofreni, otizm, obsesif kompulsif bozukluk ve Alzheimer hastalığında incelenmiş ve anlamlı sonuçlar bulunmuştur. Uzun yıllardır yapılan araştırmalara rağmen duygudurum düzenleyici ilaçların mekanizmaları henüz açık değildir. Önceki çalışmalarda, iki uçlu duygudurum bozukluğunda (İDB) antimanik tedavi ile oksidatif stres parametrelerinin düştüğü gösterilmiştir. Çalışmalar lityumun antioksidan etkilerini açıkça göstermiştir. Lityumun çeşitli hedeflere olan düzenleyici etkileri ile oksidatif hasara karşı nöroprotektif etkiler ürettiği öne sürülebilir. Lityumun nitrik oksit sentaz enzimi üzerindeki etkileri laboratuvar çalışmalarında incelenmiştir. Bu çalışmada İDB tip I (İDB-I) hastalarının akut mani ve lityum ile tedavi sonrası ötimi dönemlerinde, plazma NO ve ADMA seviyelerinin karşılaştırılması amaçlanmıştır. Yöntem: Çalışmaya Karadeniz Teknik Üniversitesi Farabi Hastanesi’ne başvuran, DSM-IV-TR’ye göre İDB-I mani nöbeti tanısı konulan ve lityumla izlenen 17 hasta alınmıştır. Hastalık dönemleri ve ötimi dönemlerinde hastalara SCID-I, HAM-D, YMRS, MADRS ölçekleri uygulanmıştır. Hastalardan mani ve ötimi dönemlerinde NO ve ADMA tayini için, iki tüp plazma örneği alınmıştır. Bulgular: Tedavi öncesi gruba göre tedavi sonrası grupta ADMA düzeyi anlamlı olarak düşerken, NO düzeyi anlamlı olarak yükselmiştir. Sonuç: Bu çalışmada, lityum tedavisi sonrasında İDB mani nöbeti hastalarının NO plazma düzeyinde artma ve ADMA plazma düzeyinde azalma görüldüğü, lityumun tedavi edici etkisine bu mekanizmanın katkıda bulunabileceği gösterilmiştir.

Anahtar Kelimeler: İki uçlu duygudurum bozukluğu tip I, nitrik oksit (NO), asimetrik dimetilarginin (ADMA), lityum


 
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Pubmed Style

Tiryaki A, Aykut DS, Karaguzel EO, Karahan SC. [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anadolu Psikiyatri Derg. 2017; 18(1): 29-35. Turkish. doi:10.5455/apd.214841


Web Style

Tiryaki A, Aykut DS, Karaguzel EO, Karahan SC. [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. http://www.anadolupsikiyatri.net/?mno=214841 [Access: July 21, 2018]. Turkish. doi:10.5455/apd.214841


AMA (American Medical Association) Style

Tiryaki A, Aykut DS, Karaguzel EO, Karahan SC. [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anadolu Psikiyatri Derg. 2017; 18(1): 29-35. Turkish. doi:10.5455/apd.214841



Vancouver/ICMJE Style

Tiryaki A, Aykut DS, Karaguzel EO, Karahan SC. [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anadolu Psikiyatri Derg. (2017), [cited July 21, 2018]; 18(1): 29-35. Turkish. doi:10.5455/apd.214841



Harvard Style

Tiryaki, A., Aykut, D. S., Karaguzel, E. O. & Karahan, S. C. (2017) [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anadolu Psikiyatri Derg, 18 (1), 29-35. Turkish. doi:10.5455/apd.214841



Turabian Style

Tiryaki, Ahmet, Demet Saglam Aykut, Evrim Ozkorumak Karaguzel, and Suleyman Caner Karahan. 2017. [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anatolian Journal of Psychiatry, 18 (1), 29-35. Turkish. doi:10.5455/apd.214841



Chicago Style

Tiryaki, Ahmet, Demet Saglam Aykut, Evrim Ozkorumak Karaguzel, and Suleyman Caner Karahan. "[Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]." Anatolian Journal of Psychiatry 18 (2017), 29-35. Turkish. doi:10.5455/apd.214841



MLA (The Modern Language Association) Style

Tiryaki, Ahmet, Demet Saglam Aykut, Evrim Ozkorumak Karaguzel, and Suleyman Caner Karahan. "[Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]." Anatolian Journal of Psychiatry 18.1 (2017), 29-35. Print.Turkish. doi:10.5455/apd.214841



APA (American Psychological Association) Style

Tiryaki, A., Aykut, D. S., Karaguzel, E. O. & Karahan, S. C. (2017) [Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment]. Anatolian Journal of Psychiatry, 18 (1), 29-35. Turkish. doi:10.5455/apd.214841





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