ISSN 1302-6631
 

Original Research (Original Article) 


Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder

Mehmet Asoğlu, Fethiye Kılıçaslan, Özlem Beginoğlu, Ülker Fedai, Öznur Akıl, Hakim Çelik, Hasan Büyükaslan.

Abstract
Objectives: Previous studies have investigated the role of oxidative stress in the etiology of generalized anxiety disorder (GAD). Thiols are an important component of the antioxidant buffer system. Dynamic thiol/disulphide homeostasis is a system that has a significant role in processes such as antioxidation preservation and regulation of enzymatic reactions. However, the value of dynamic thiol/disulphide homeostasis in etiopathogenesis of GAD has not been documented. The goal of this study was to determine dynamic thiol/disulphide homeostasis, which has an important role in antioxidant defense in untreated patients with GAD. Methods: This study included 25 patients who were diagnosed with GAD and 24 age-matched healthy controls. In both groups, thiol/disulphide homeostasis was assessed using an automated assay method. The Hamilton Anxiety Rating Scale (HAM-A) was used to determine the anxiety levels of patients with GAD.Results: Patients with GAD had higher total thiol and native thiol levels compared to the control group, but the differences were not statistically significant. In patients with GAD, the dynamic disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were higher compared to the control group. However, the native thiol-to-total thiol ratio was significantly lower in patients with GAD compared to the control group (p=0.020). Pearson’s correlation analysis showed no statistically significant correlations between total HAM-A scores and oxidative stress parameter levels in the patient group. Conclusions: This is the first report to assess the thiol/disulphide homeostasis in GAD patients. Our study provides evidence that the disulphide-to-native thiol and disulphide-to-total thiol ratios are higher in untreated patients with GAD than in the control group. This suggests that thiol/ disulfide homeostasis is impaired in GAD patients.

Key words: Genaralized anxiety disorder , oxidative stress, thyol-disulfide homeostase



Tedavi edilmemiş yaygın anksiyete bozukluğu olan hastalarda yeni bir oksidatif stres belirleyicisi olan tiyol/disülfid homeostazı

Ozet
Amaç: Önceki çalışmalarda, yaygın anksiyete bozukluğunun (YAB) etiyolojisinde, oksidatif stresin rolü araştırılmıştır. Tiyoller antioksidan savunma sisteminin önemli bir bileşenidir. Dinamik tiyol/disülfid homeostazı, antioksidan savunma sistemi ve enzimatik reaksiyonların düzenlenmesi gibi süreçlerde, önemli bir role sahiptir. Bununla birlikte, YAB'nin etiyopatogenezinde dinamik tiyol/disülfid homeostazının önemine ilişkin herhangi bir çalışma yoktur. Bu çalışmanın amacı tedavi edilmeyen YAB hastalarında, oksidan/antioksidan dengenin önemli bir göstergesi olan dinamik tiyol/disülfid homeostazını araştırmaktır. Yöntem: Çalışmaya YAB’li 25 hasta ile, yaşları uyumlu 24 sağlıklı kontrol alındı. Her iki grupta, tiyol/disülfid homeostaz parametreleri, yeni ve tam otomatik bir yöntem ile analiz edildi. YAB'li hastaların anksiyete düzeylerini belirlemek için Hamilton Anksiyete Derecelendirme Ölçeği (HAM-A) kullanıldı. Bulgular: YAB olan hastaların total tiyol ve natif tiyol düzeyleri, kontrol grubuna göre daha yüksekti, ancak istatistiksel olarak anlamlı fark bulunmadı. YAB'li hastalarda disülfid düzeyleri, disülfid/natif tiyol ve disülfid/total tiyol oranları, kontrol grubuna göre daha yüksek bulundu. Bununla birlikte, natif tiyol/total tiyol oranı, YAB hastalarında, kontrol grubuna göre anlamlı derecede düşük bulundu. Hasta grubundaki HAM-A puanları ile oksidatif stres parametreleri arasında, istatistiksel olarak anlamlı bir ilişki saptanmadı. Sonuç: Bu çalışma, YAB hastalarında, tiyol/disülfid homeostazını değerlendiren ilk çalışmadır. Çalışmamız, disülfid/natif tiyol ve disülfit/total tiyol oranlarının, tedavi edilmemiş YAB hastalarında, kontrol grubuna göre daha yüksek olduğuna ilişkin kanıtlar sunmaktadır. Bu durum YAB hastalarında tiyol/disülfid homeostazının bozulduğunu göstermektedir.

Anahtar Kelimeler: Yaygın anksiyete bozukluğu, oksidatif stres, tiyol/disülfid homeostazı


 
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Pubmed Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anadolu Psikiyatri Derg. 2018; 19(2): 143-149. doi:10.5455/apd.261956


Web Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. http://www.anadolupsikiyatri.net/?mno=261956 [Access: December 13, 2018]. doi:10.5455/apd.261956


AMA (American Medical Association) Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anadolu Psikiyatri Derg. 2018; 19(2): 143-149. doi:10.5455/apd.261956



Vancouver/ICMJE Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anadolu Psikiyatri Derg. (2018), [cited December 13, 2018]; 19(2): 143-149. doi:10.5455/apd.261956



Harvard Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan (2018) Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anadolu Psikiyatri Derg, 19 (2), 143-149. doi:10.5455/apd.261956



Turabian Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. 2018. Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anatolian Journal of Psychiatry, 19 (2), 143-149. doi:10.5455/apd.261956



Chicago Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. "Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder." Anatolian Journal of Psychiatry 19 (2018), 143-149. doi:10.5455/apd.261956



MLA (The Modern Language Association) Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan. "Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder." Anatolian Journal of Psychiatry 19.2 (2018), 143-149. Print. doi:10.5455/apd.261956



APA (American Psychological Association) Style

Mehmet Asoglu, Fethiye Kilicaslan, Ozlem Beginoglu, Ulker Fedai, Oznur Akil, Hakim Celik, Hasan Buyukaslan (2018) Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder. Anatolian Journal of Psychiatry, 19 (2), 143-149. doi:10.5455/apd.261956





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