ISSN 1302-6631
 

Original Research (Original Article) 


Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients

Lale Gönenir Erbay, Nursel Aktı Kavuran, Çağatay Taşkapan, Lara Utku İnce, Saim Yoloğlu, Hüsniye Gül Temelli, Süheyla Ünal.

Abstract
Objective: Increasing evidence suggests that certain inflammatory factors, especially cytokines, can lead to neurochemical and behavioral changes via their role in the brain signaling system. Studies investigating cytokine abnormalities in obsessive-compulsive disorder (OCD) have yielded conflicting results thus far. The aim of this study was to investigate the serum IL-1, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free patients with OCD. Methods: Forty comorbidity-free, drug-free OCD patients and 40 age- and sex-matched healthy volunteers were included in the study. Clinical severity was assessed using the Yale-Brown Obsessive-Compulsive Evaluation Scale (YBOCES). Results: IL-1 levels were significantly higher and IL-2, IL-6, and TNF-α levels were significantly lower in patients than in controls. No differences were observed in IL-4, IL-10, and IFN-γ levels. How-ever, a negative relationship was found between IL-1 levels and compulsive symptoms (YBOCES) in OCD patients. Conclusions: Our findings suggest the possible role of cytokines in the pathogenesis of OCD. It is important to continue investigating the role of cytokines and other immunological markers in both the etiology and treatment of OCD.

Key words: OCD, cytokines, immunological markers



İlaç kullanmayan ve komorbiditesi olmayan obsesif kompulsif bozukluk hastalarında serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α ve IFN-γ düzeyleri

Özet
Amaç: Bazı inflamatuar etkenlerin beyin sinyalizasyon sistemindeki rolü bilinmektedir. Artan kanıtlar, bu inflamatuar etkenlerin en önemlileri olan sitokinlerin nörokimyasal ve davranışsal değişikliklere neden olabileceğini düşündürmektedir. Obsesif kompulsif bozukluktaki (OKB) sitokin anormalliklerini araştıran çalışmalar şimdiye kadar çelişkili sonuçlar vermiştir. Bu çalışmanın amacı, ilaçsız, komorbiditesi olmayan OKB hastalarında serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α ve IFN-γ düzeylerini araştırmaktır. Yöntem: Çalışmaya komorbiditesi olmayan ve ilaç kullanma-yan 40 OKB hastası ile yaş ve cinsiyet açısından eşleştirilmiş 40 sağlıklı gönüllü alındı. Klinik şiddet Yale Brown Obsesyon Kompulsiyon Ölçeği (YBOKÖ) kullanılarak değerlendirildi. Bulgular: IL-1 düzeyleri hastalarda anlamlı olarak yüksekti. IL-2, IL-6 ve TNF-α düzeyleri ise hastalarda kontrollerden daha düşüktü. IL-4, IL-10 ve IFN-γ düzeyleri için herhangi bir fark gözlemlenmedi. Bununla birlikte, OKB hastalarında IL-1 düzeyleri ile kompulsiyon (YBOKÖ) puanları arasında negatif korelasyon saptandı. Tartışma: Bulgularımız, OKB patogenezinde sitokinlerin olası rolünü ileri sürmektedir. Hem etiyoloji, hem de yeni tedavi hedefleri açısından OKB'de sitokinlerin ve diğer immunolojik belirteçlerin rolünü araştıracak ileri çalışmalara gerek vardır.

Anahtar Kelimeler: OKB, sitokin, immünolojik belirteçler


 
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Pubmed Style

Erbay LG, Kavuran NA, Taskapan C, Ince LU, Yologlu S, Temelli HG, Unal S. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anadolu Psikiyatri Derg. 2018; 19(2): 157-162. doi:10.5455/apd.274680


Web Style

Erbay LG, Kavuran NA, Taskapan C, Ince LU, Yologlu S, Temelli HG, Unal S. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. http://www.anadolupsikiyatri.net/?mno=274680 [Access: June 20, 2018]. doi:10.5455/apd.274680


AMA (American Medical Association) Style

Erbay LG, Kavuran NA, Taskapan C, Ince LU, Yologlu S, Temelli HG, Unal S. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anadolu Psikiyatri Derg. 2018; 19(2): 157-162. doi:10.5455/apd.274680



Vancouver/ICMJE Style

Erbay LG, Kavuran NA, Taskapan C, Ince LU, Yologlu S, Temelli HG, Unal S. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anadolu Psikiyatri Derg. (2018), [cited June 20, 2018]; 19(2): 157-162. doi:10.5455/apd.274680



Harvard Style

Erbay, L. G., Kavuran, N. A., Taskapan, C., Ince, L. U., Yologlu, S., Temelli, H. G. & Unal, S. (2018) Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anadolu Psikiyatri Derg, 19 (2), 157-162. doi:10.5455/apd.274680



Turabian Style

Erbay, Lale Gonenir, Nursel Akti Kavuran, Cagatay Taskapan, Lara Utku Ince, Saim Yologlu, Husniye Gul Temelli, and Suheyla Unal. 2018. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anatolian Journal of Psychiatry, 19 (2), 157-162. doi:10.5455/apd.274680



Chicago Style

Erbay, Lale Gonenir, Nursel Akti Kavuran, Cagatay Taskapan, Lara Utku Ince, Saim Yologlu, Husniye Gul Temelli, and Suheyla Unal. "Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients." Anatolian Journal of Psychiatry 19 (2018), 157-162. doi:10.5455/apd.274680



MLA (The Modern Language Association) Style

Erbay, Lale Gonenir, Nursel Akti Kavuran, Cagatay Taskapan, Lara Utku Ince, Saim Yologlu, Husniye Gul Temelli, and Suheyla Unal. "Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients." Anatolian Journal of Psychiatry 19.2 (2018), 157-162. Print. doi:10.5455/apd.274680



APA (American Psychological Association) Style

Erbay, L. G., Kavuran, N. A., Taskapan, C., Ince, L. U., Yologlu, S., Temelli, H. G. & Unal, S. (2018) Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anatolian Journal of Psychiatry, 19 (2), 157-162. doi:10.5455/apd.274680





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