ISSN 1302-6631
 

Original Research (Original Article) 


Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Hayriye Baykan, Onur Durmaz, Özgür Baykan, Murat Alışık, Merve Şahin Can, Tunay Karlıdere, Özcan Erel.

Abstract
Objective: We aimed to investigate the oxidative stress status in a population of women with untreated major depressive disorder. Methods: Fifty-four female patients with untreated major depressive disorder and 68 female healthy controls were included in the study. A Sociodemographic Form, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale (HAM-D) were applied to all the participants. Fasting blood samples were collected from all participants to assess serum thiol/disulphide levels and their pairwise ratios. Results: Native thiol levels were significantly higher and disulphide levels were lower in patients as compared to controls, while total thiol levels were not significantly different between the groups. Disulphide/native thiol and disulphide/total thiol ratios were significantly lower, while the native thiol/total thiol ratio was significantly higher, in the patient group than the control group. There was a negative correlation between HAM-D score and disulphide level, disulphide/native thiol ratio, and disulphide/total ratio, while there was a positive correlation between HAM-D score and native/total thiol ratio, in the patient group. Discussion: This is the first study to investigate dynamic thiol/disulphide homeostasis in women with untreated major depressive disorder. Our results showed dynamic thiol/disulphide homeostasis shifts towards thiol formation which implies an antioxidant reaction in women with untreated major depressive disorder.

Key words: depression; oxidative stress; female; thiol; disulphide



Majör depresif bozukluk tanılı kadın hastalarda yeni bir oksidatif belirteç olarak tiyol/disülfid dengesi

Ozet
Amaç: Bu çalışmada majör depresif bozukluğu olan kadın hastalarda oksidatif stres durumunu değerlendirmeyi amaçladık. Yöntem: Çalışmaya ilaç tedavisi görmeyen majör depresif bozukluğu olan 44 kadın hasta ve 68 sağlıklı kadın alındı. Sosyodemografik Form, Hamilton Anksiyete Derecelendirme Ölçeği, Hamilton Depresyon Derecelendirme Ölçeği (HAM-D) tüm örneklemlere uygulandı. Serum tiyol/disülfid düzeyleri tüm katılımcılardan alınmış açlık kan örnekleri değerlendirilerek ölçüldü. Bulgular: Serum native tiyol düzeyleri hasta grubunda kontrol grubuna göre anlamlı düzeyde daha yüksek saptanırken, serum disülfid düzeyleri anlamlı düzeyde daha düşük saptandı. Serum total tiyol düzeyleri açısından gruplar arasında anlamlı fark yoktu. Hasta grubunda serum disülfid/native tiyol ve serum disülfid/total tiyol oranları anlamlı düzeyde düşük iken, serum native tiyol/total tiyol oranı anlamlı düzeyde yüksek saptandı. Hastaların HAM-D puanı ve serum disülfid düzeyi, disülfid/native tiyol oranı, disülfid/total tiyol oranı arasında negatif korelasyon, HAM-D puanı ve serum native tiyol/total tiyol oranı arasında pozitif korelasyon vardı. Tartışma: Çalışmamız tedavisiz majör depresyon tanılı kadınlarda dinamik tiyol/disülfid dengesini inceleyen ilk çalışmadır. Çalışmamızın sonuçları tedavisiz majör depresyon tanılı kadınlarda dinamik tiyol/disülfid dengesinin antioksidatif bir reaksiyonu düşündürecek şekilde tiyol oluşumu yönünde olduğunu göstermiştir.

Anahtar Kelimeler: depresyon; oksidatif stres; kadın; tiyol; disülfid


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Hayriye Baykan
Articles by Onur Durmaz
Articles by Özgür Baykan
Articles by Murat Alışık
Articles by Merve Şahin Can
Articles by Tunay Karlıdere
Articles by Özcan Erel
on Google
on Google Scholar
Article Statistics
 Viewed: 1229
Downloaded: 567
Cited: 0

How to Cite this Article
Pubmed Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anadolu Psikiyatri Derg. 2018; 19(2): 135-142. doi:10.5455/apd.275045


Web Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. http://www.anadolupsikiyatri.net/?mno=275045 [Access: December 13, 2018]. doi:10.5455/apd.275045


AMA (American Medical Association) Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anadolu Psikiyatri Derg. 2018; 19(2): 135-142. doi:10.5455/apd.275045



Vancouver/ICMJE Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anadolu Psikiyatri Derg. (2018), [cited December 13, 2018]; 19(2): 135-142. doi:10.5455/apd.275045



Harvard Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel (2018) Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anadolu Psikiyatri Derg, 19 (2), 135-142. doi:10.5455/apd.275045



Turabian Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. 2018. Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anatolian Journal of Psychiatry, 19 (2), 135-142. doi:10.5455/apd.275045



Chicago Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. "Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder." Anatolian Journal of Psychiatry 19 (2018), 135-142. doi:10.5455/apd.275045



MLA (The Modern Language Association) Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel. "Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder." Anatolian Journal of Psychiatry 19.2 (2018), 135-142. Print. doi:10.5455/apd.275045



APA (American Psychological Association) Style

Hayriye Baykan, Onur Durmaz, Ozgur Baykan, Murat Alisik, Merve Sahin Can, Tunay Karlidere, Ozcan Erel (2018) Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder. Anatolian Journal of Psychiatry, 19 (2), 135-142. doi:10.5455/apd.275045





Most Viewed Articles
  • Schizophrenia and mega cisterna magna: case report [Turkish]
    Semra Karayılan, Atila Erol
    Anadolu Psikiyatri Derg. 2013; 14(1): 90-92
    » Abstract & References » doi: 10.5455/apd.36699

  • Impulsivity in patients with obesity and correlations with body perception and self-esteem [Turkish]
    G Sarısoy, A Atmaca, G Ecemiş, K Gümüş, O Pazvantoğlu
    Anadolu Psikiyatri Derg. 2013; 14(1): 53-61
    » Abstract & References » doi: 10.5455/apd.34469

  • The relationship between aggression and online video game addiction: a study on massively multiplayer online video game players [Turkish]
    H. Andaç Demirtaş Madran, Eda Ferligül Çakılcı
    Anadolu Psikiyatri Derg. 2014; 15(2): 99-107
    » Abstract & References » doi: 10.5455/apd.39828

  • Reliability and validity of the Morisky Medication Adherence Scale for bipolar mood disorder [Turkish]
    Güven Bahar, Haluk A. Savaş, Ahmet Ünal, Esen Savaş, Hilal Kaya, Aynur Bahar
    Anadolu Psikiyatri Derg. 2014; 15(2): 141-149
    » Abstract & References » doi: 10.5455/apd.39827

  • The effects of the service of community mental health center on the patients with schizophrenia - evaluation of quality of life, disabilities, general and social functioning- a summary of one year follow-up [Turkish]
    Hülya Ensari, Bülent Kadri Gültekin, Derya Karaman, Ayşegül Koç, Ali Fuat Beşkardeş
    Anadolu Psikiyatri Derg. 2013; 14(2): 108-114
    » Abstract & References » doi: 10.5455/apd.36380

  • Cases of sibling incest resulting in pregnancy [Turkish]
    Evrim Aktepe, Orhan Kocaman
    Anadolu Psikiyatri Derg. 2013; 14(2): 177-180
    » Abstract & References » doi: 10.5455/apd.35965

  • The Scale of Positive and Negative Experience: a validity and reliability study for adolescents [Turkish]
    Bülent Baki Telef
    Anadolu Psikiyatri Derg. 2013; 14(1): 62-68
    » Abstract & References » doi: 10.5455/apd.36692

  • Eating disorders and psychosis [Turkish]
    Vesile Altınyazar, Fulya Maner
    Anadolu Psikiyatri Derg. 2014; 15(1): 84-88
    » Abstract & References » doi: 10.5455/apd.38073

  • Job satisfaction and perceived job stress of the health professionals and the relationship between them [Turkish]
    Etem Erdal Erşan, Gülay Yıldırım, Orhan Doğan, Selma Doğan
    Anadolu Psikiyatri Derg. 2013; 14(2): 115-121
    » Abstract & References » doi: 10.5455/apd.34482

  • Death anxiety in elderly cases [Turkish]
    Zehra Öztürk, Gonca Karakuş, Lut Tamam
    Anadolu Psikiyatri Derg. 2011; 12(1): 37-43
    » Abstract

  • Most Downloaded
  • Educational needs assessment of stigmatization towards mental illness in medical education: qualitative and quantitative approach [Turkish]
    Meral Demirören, Yeşim Şenol, Ayşen Melek Aytuğ-Koşan, Meram Can Saka
    Anadolu Psikiyatri Derg. 2015; 16(1): 22-29
    » Abstract & References » doi: 10.5455/apd.45731

  • Frontal Lobe Syndrome Developing After Head Trauma: Case Report [Turkish]
    Betül Çevik, Ali Yıldırım, Dürdane Aksoy, Erdal Özer, Semiha Kurt
    Anadolu Psikiyatri Derg. 2015; 16(3): 223-226
    » Abstract & References » doi: 10.5455/apd.155354

  • Impulsivity in patients with obesity and correlations with body perception and self-esteem [Turkish]
    G Sarısoy, A Atmaca, G Ecemiş, K Gümüş, O Pazvantoğlu
    Anadolu Psikiyatri Derg. 2013; 14(1): 53-61
    » Abstract & References » doi: 10.5455/apd.34469

  • Schizophrenia and mega cisterna magna: case report [Turkish]
    Semra Karayılan, Atila Erol
    Anadolu Psikiyatri Derg. 2013; 14(1): 90-92
    » Abstract & References » doi: 10.5455/apd.36699

  • Investigation of mindfulness and affecting factors of mindfulness among substance users and non users [Turkish]
    Kültegin Ögel, Nuray Sarp, Defne Tamar Gürol, Eda Ermağan
    Anadolu Psikiyatri Derg. 2014; 15(4): 282-288
    » Abstract & References » doi: 10.5455/apd.169583

  • Characteristic features of perpetrators of sexual abuse on children and adolescents in four different regions of Turkey [Turkish]
    Ayten Erdoğan, Evren Tufan, Mehmet Gökşin Karaman, Mehmet Süleyman Atabek, Cem Koparan, Esra Özdemir, Anna Baranova Çetiner, Nihal Yurteri, Ülkem Öztürk, Mehmet Ali Kurçer, Handan Ankaralı
    Anadolu Psikiyatri Derg. 2011; 12(1): 55-61
    » Abstract

  • Validity and reliability of the Turkish version of the Smartphone Addiction Scale-Short Version among university students [Turkish]
    Cemal Onur Noyan, Aslı Enez Darçın, Serdar Nurmedov, Onat Yılmaz , Nesrin Dilbaz
    Anadolu Psikiyatri Derg. 2015; 16(Supplement 1): 73-81
    » Abstract & References » doi: 10.5455/apd.176101

  • Arachnoid cysts accompanied with psychiatric symptoms: Case series [Turkish]
    Sıla Yazar, Nurhan Fıstıkcı, Gülsüm Cantürk, Serap Oflaz, Ali Haydar Küçüktüfekçi, Alkin Yılmaz, Demet Yandım Kuşçu
    Anadolu Psikiyatri Derg. 2013; 14(1): 87-89
    » Abstract & References » doi: 10.5455/apd.35964

  • The relationship between smoking & alcohol use and internet addiction among the university students [Turkish]
    Hüseyin Alaçam, Figen Çulha Ateşçi, Abdullah Cem Şengül, Selim Tümkaya
    Anadolu Psikiyatri Derg. 2015; 16(6): 383-388
    » Abstract & References » doi: 10.5455/apd.172340

  • Death anxiety in elderly cases [Turkish]
    Zehra Öztürk, Gonca Karakuş, Lut Tamam
    Anadolu Psikiyatri Derg. 2011; 12(1): 37-43
    » Abstract

  • Most Cited Articles
  • Burnout, job satisfaction and depression in the healthcare personnel who work in the emergency department [Turkish]
    Cem Gökçen, Suat Zengin, Mehmet Murat Oktay, Gökay Alpak, Behçet Al, Cuma Yıldırım
    Anadolu Psikiyatri Derg. 2013; 14(2): 122-128
    » Abstract & References » doi: 10.5455/apd.36379
    Cited : 8 times [Click to see citing articles]

  • Validity and reliability of the Turkish version of the Smartphone Addiction Scale-Short Version among university students [Turkish]
    Cemal Onur Noyan, Aslı Enez Darçın, Serdar Nurmedov, Onat Yılmaz , Nesrin Dilbaz
    Anadolu Psikiyatri Derg. 2015; 16(Supplement 1): 73-81
    » Abstract & References » doi: 10.5455/apd.176101
    Cited : 8 times [Click to see citing articles]

  • The Scale of Positive and Negative Experience: a validity and reliability study for adolescents [Turkish]
    Bülent Baki Telef
    Anadolu Psikiyatri Derg. 2013; 14(1): 62-68
    » Abstract & References » doi: 10.5455/apd.36692
    Cited : 5 times [Click to see citing articles]

  • The reliability and validity of Turkish version of The Night Eating Questionnaire in psychiatric outpatient population [Turkish]
    Nuray Atasoy, Özge Saraçlı, Numan Konuk, Handan Ankaralı, S. Olga Güriz, Asena Akdemir, Güzin Mukaddes Sevinçer, Levent Atik
    Anadolu Psikiyatri Derg. 2014; 15(3): 238-247
    » Abstract & References » doi: 10.5455/apd.39829
    Cited : 5 times [Click to see citing articles]

  • The prediction level of caregiver burden on caregivers’ state-trait anxiety levels [Turkish]
    Zümra Özyeşil, Aslin Oluk, Duran Çakmak
    Anadolu Psikiyatri Derg. 2014; 15(1): 39-44
    » Abstract & References » doi: 10.5455/apd.39820
    Cited : 5 times [Click to see citing articles]

  • Psychometric properties of the Turkish version of the Yale Food Addiction Scale among bariatric surgery patients [English]
    Güzin Mukaddes Sevinçer, Numan Konuk, Süleyman Bozkurt, Özge Saraçlı, Halil Coşkun
    Anadolu Psikiyatri Derg. 2015; 16(Supplement 1): 44-53
    » Abstract & References » doi: 10.5455/apd.174345
    Cited : 5 times [Click to see citing articles]

  • The effects of the service of community mental health center on the patients with schizophrenia - evaluation of quality of life, disabilities, general and social functioning- a summary of one year follow-up [Turkish]
    Hülya Ensari, Bülent Kadri Gültekin, Derya Karaman, Ayşegül Koç, Ali Fuat Beşkardeş
    Anadolu Psikiyatri Derg. 2013; 14(2): 108-114
    » Abstract & References » doi: 10.5455/apd.36380
    Cited : 4 times [Click to see citing articles]

  • Childhood trauma in recurrent and first episode depression [Turkish]
    Feridun Bülbül, Ülkü Çakır, Cuma Ülkü, İdris Üre, Onur Karabatak, Gökay Alpak
    Anadolu Psikiyatri Derg. 2013; 14(2): 93-99
    » Abstract & References » doi: 10.5455/apd.34484
    Cited : 4 times [Click to see citing articles]

  • An evaluation of the quality of life of children with attention-deficit/hyperactivity disorder (ADHD) and their families [English]
    Hasan Kandemir, Birim Günay Kılıç, Suat Ekinci, Murat Yüce
    Anadolu Psikiyatri Derg. 2014; 15(3): 265-271
    » Abstract & References » doi: 10.5455/apd.46202
    Cited : 4 times [Click to see citing articles]

  • Sociodemographic characteristics and psychiatric evaluation of girls who were married at younger age and referred for criminal evaluation [Turkish]
    Nusret Soylu, Muhammed Ayaz
    Anadolu Psikiyatri Derg. 2013; 14(2): 136-144
    » Abstract & References » doi: 10.5455/apd.36694
    Cited : 3 times [Click to see citing articles]