ISSN 1302-6631
 

Original Research (Original Article) 


A comparative study of the oxidative stress indices of children with autism and healthy children

Çağatay Uğur, Hüseyin Tunca, Ebru Sekmen, Özden Şükran Üneri, Murat Alişik, Özcan Erel, Esra Solmaz.

Abstract
Objective: This study was aimed to analyze the serum total antioxidant/total oxidant (TAS/TOS) levels and thiol/ disulphide balance of children with autism spectrum disorders (ASD) and draws a comparison with those of healthy children. Methods: The study involved 46 children diagnosed with ASD, along with 45 healthy children. The developmental stage, degree of intelligence and autism symptom severity of the ASD group were assessed using the Autism Behavior Checklist (ABC), Problematic Behavior Control List (PBCL), Childhood Autism Checklist Scale (CARS) and developmentally appropriate screening or IQ tests. Clinical, sociological and demographic data were obtained for both groups. The TAS/TOS levels and thiol/disulphide balance of both groups were analyzed and their oxidative stress index was obtained from the formula TAS/TOSx100. SPSS 17.0 was used for statistical analyses. p<0.05 was accepted to be statistically significant. Results: While lower TAS, native thiol and total thiol levels were found in the ASD group, other indices such as TOS, OSI and serum thiol-disulphide were similar for both groups. Discussion: Although no measurable effect upon the severity of autism was noted, the total antioxidant and thiol levels may be a significant cause of oxidative imbalance in ASD and our findings may suggest a predictive usefulness for TAS/TOS and thiol/disulphide balance, suggesting that treatments for ASD that take advantage of the potential advantages of antioxidants should be developed.

Key words: Autism, oxidative stress, antioxidants, thiol-disulphide, TAS, TOS, OSI, child.



Oksidatif stres göstergelerinin otizmli ve sağlıklı çocuklarda karşılaştırmalı bir çalışması

Özet
Amaç: Bu çalışmada otizm yelpazesi bozukluğu (OYB) olan çocuklarda ve sağlıklı çocuklarda serum total antioksidan/oksidan (TAS/TOS) düzeyleri ile tiyol-disülfid dengesi çalışılarak karşılaştırılması amaçlandı. Yöntem: OYB’li 46 çocuk ile 45 sağlıklı çocuk çalışmaya alındı. OYB’li çocukların gelişim evreleri, zeka düzeyleri ve otizm belirti şiddeti düzeyleri Otizm Davranış Kontrol Listesi (ODKL), Sorun Davranış Kontrol Listesi (SDKL), Çocukluk Otizmi Değerlendirme Ölçeği (ÇODÖ) ve yaş gruplarına uygun gelişim tarama ölçeği ve/veya zeka testleri ile değerlendirildi. İki grubun klinik, sosyodemografik değişkenlere ait verileri toplandı. TAS/TOS düzeyleri, tiyol-disülfid dengesi iki grupta da analiz edildi. Oksidatif stres indeksleri (OSI) TAS/TOSx100 formülü kullanılarak hesaplandı. İstatistiksel analizlerde SPSS 17.0 kullanıldı. p<0.05 anlamlılık düzeyi olarak kabul edildi. Sonuç: TAS, native tiyol ve total tiyol düzeylerinin OYB’li grupta daha düşük olduğu, TOS, OSI ve serum tiyol-disülfid dengesinin iki grupta birbirine benzer oldukları saptandı. Tartışma: Otizmin şiddeti ile arasında bir ilişki bulunamamasına karşın, total antioksidanlar ve tiyol düzeyleri OYB’ de oksidatif dengesizliğe yol açabilir. Bulgularımız TAS/TOS ve tiyol-disülfid dengesinin öngördürücü olabilirliğini desteklemekte olup antioksidanların potansiyel tedavi seçenekleri arasında olduğunu düşündürmektedir.

Anahtar Kelimeler: otizm, oksidatif stress, antioksidanlar, tiyol-disülfit, TAS, TOS, OSI, çocuk


 
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Pubmed Style

Ugur C, Tunca H, Sekmen E, Uneri OS, Alisik M, Erel O, Solmaz E. A comparative study of the oxidative stress indices of children with autism and healthy children. Anadolu Psikiyatri Derg. 2018; 19(3): 314-322. doi:10.5455/apd.276094


Web Style

Ugur C, Tunca H, Sekmen E, Uneri OS, Alisik M, Erel O, Solmaz E. A comparative study of the oxidative stress indices of children with autism and healthy children. http://www.anadolupsikiyatri.net/?mno=276094 [Access: June 20, 2018]. doi:10.5455/apd.276094


AMA (American Medical Association) Style

Ugur C, Tunca H, Sekmen E, Uneri OS, Alisik M, Erel O, Solmaz E. A comparative study of the oxidative stress indices of children with autism and healthy children. Anadolu Psikiyatri Derg. 2018; 19(3): 314-322. doi:10.5455/apd.276094



Vancouver/ICMJE Style

Ugur C, Tunca H, Sekmen E, Uneri OS, Alisik M, Erel O, Solmaz E. A comparative study of the oxidative stress indices of children with autism and healthy children. Anadolu Psikiyatri Derg. (2018), [cited June 20, 2018]; 19(3): 314-322. doi:10.5455/apd.276094



Harvard Style

Ugur, C., Tunca, H., Sekmen, E., Uneri, O. S., Alisik, M., Erel, O. & Solmaz, E. (2018) A comparative study of the oxidative stress indices of children with autism and healthy children. Anadolu Psikiyatri Derg, 19 (3), 314-322. doi:10.5455/apd.276094



Turabian Style

Ugur, Cagatay, Huseyin Tunca, Ebru Sekmen, Ozden Sukran Uneri, Murat Alisik, Ozcan Erel, and Esra Solmaz. 2018. A comparative study of the oxidative stress indices of children with autism and healthy children. Anatolian Journal of Psychiatry, 19 (3), 314-322. doi:10.5455/apd.276094



Chicago Style

Ugur, Cagatay, Huseyin Tunca, Ebru Sekmen, Ozden Sukran Uneri, Murat Alisik, Ozcan Erel, and Esra Solmaz. "A comparative study of the oxidative stress indices of children with autism and healthy children." Anatolian Journal of Psychiatry 19 (2018), 314-322. doi:10.5455/apd.276094



MLA (The Modern Language Association) Style

Ugur, Cagatay, Huseyin Tunca, Ebru Sekmen, Ozden Sukran Uneri, Murat Alisik, Ozcan Erel, and Esra Solmaz. "A comparative study of the oxidative stress indices of children with autism and healthy children." Anatolian Journal of Psychiatry 19.3 (2018), 314-322. Print. doi:10.5455/apd.276094



APA (American Psychological Association) Style

Ugur, C., Tunca, H., Sekmen, E., Uneri, O. S., Alisik, M., Erel, O. & Solmaz, E. (2018) A comparative study of the oxidative stress indices of children with autism and healthy children. Anatolian Journal of Psychiatry, 19 (3), 314-322. doi:10.5455/apd.276094





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