ISSN 1302-6631
 

Original Research (Original Article) 


Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

Ayşe Kutlu, Nagihan Cevher Binici.

Abstract
Objective: Although autism spectrum disorder (ASD) is one of the most studied neurodevelopmental disorders, its etiology has not been fully elucidated. A growing body of evidence suggest the role of neuroinflammation in the etiology of ASD. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are markers of systemic inflammation. In this study, we aimed to evaluate NLR and PLR in children with ASD comparison to healthy controls. Methods: We reviewed the medical files of children with ASD in the ages of 2 to 5. The ASD group were consisted of drug-naïve 64 children who had complete blood count within a month of assessment. Age and sex matched 64 healthy children without any psychiatric disorders were recruited from the healthy child outpatient unit of the hospital. Results: NLRs were significantly higher in ASD. Children with ASD had significantly higher neutrophil counts but lower platelet and lymphocyte counts compared to those of healthy controls. NLR was found to be a predictor of ASD. Conclusions: Increased NLRs support the hypothesis of the involvement of neuroinflammation in the under-lying physiopathology of ASD. Even though recent evidence is not enough to suggest that in young children increased NLR levels may be used as screening and early intervention predictor, it should be kept in mind and may inspire new studies. Further longitudinal studies with larger sample size and homogeneous groups regarding the age and subtypes may clarify the inflammatory involvement in ASD.

Key words: Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, autism spectrum disorder, inflammation



Yüksek nötrofil-lenfosit oranı otizm spektrum bozukluğunu öngörebilir mi?

Ozet
Amaç: Otizm spektrum bozukluğu (OSB), üzerinde en çok çalışılan nörogelişimsel bozukluklardan biri olmasına rağmen, etiyolojisi tam olarak aydınlatılamamıştır. OSB’nin altta yatan patofizyolojisinde nöroinflamasyonun rol oynadığına ilişkin çalışmalar ve bulgular giderek artmaktadır. Nötrofil-Lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO) sistemik inflamasyonun göstergeleridir. Bu çalışmada, OSB’li çocuklarda sağlıklı kontrollere göre NLO ve TLO'yu değerlendirmeyi amaçladık. Yöntem: Bu çalışmada OSB tanısı olan 2-5 yaşları arasındaki çocukların tıbbi dosyaları gözden geçirilmiştir. Hasta grubu, daha öncesinde ilaç kullanımı olmayan ve tanı konulduğu bir ay içinde tam kan sayımı yapılan 64 çocuktan oluşmaktadır. Sağlam çocuk polikliniğinden psikiyatrik bozukluğu olmayan, yaş ve cinsiyetleri benzer 64 çocuk sağlıklı kontrol olarak çalışmaya alınmıştır. Sonuç: OSB’li çocuklarda, NLO anlamlı olarak yüksek bulunmuştur. Olgu grubunda, sağlıklı kontrollere kıyasla nötrofil sayısı daha yüksek, lenfosit ve trombosit sayısı daha düşük bulunmuştur. NLO değerlerinin OSB’yi yordadığı saptanmıştır. Tartışma: NLR yüksekliği OSB’nin etiyolojisinde nöroinflamasyon rolü olduğunu hipotezini desteklemektedir. Yeterli kanıt olmamakla birlikte küçük yaş döneminde yükselmiş NLR düzeylerinin OSB’de tarama ve erken müdahalede yorda-yıcı olabileceği görüşü yeni araştırmalara konu olabilir. Yaş ve alt grup dağılımı açısından benzer çocukları içeren daha büyük örneklemli uzun izlem çalışmaları OSB’nin etiyolojisinde inflamasyonun katkısını açıklayabilir.

Anahtar Kelimeler: Nötrofil-lenfosit oranı, trombosit-lenfosit oranı, otizm spektrum bozukluğu, inflamasyon


 
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Pubmed Style

Kutlu A, Binici NC. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339


Web Style

Kutlu A, Binici NC. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. http://www.anadolupsikiyatri.net/?mno=296339 [Access: August 16, 2018]. doi:10.5455/apd.296339


AMA (American Medical Association) Style

Kutlu A, Binici NC. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339



Vancouver/ICMJE Style

Kutlu A, Binici NC. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339



Harvard Style

Kutlu, A. & Binici, N. C. (0) Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339



Turabian Style

Kutlu, Ayse, and Nagihan Cevher Binici. 0. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339



Chicago Style

Kutlu, Ayse, and Nagihan Cevher Binici. "Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?." doi:10.5455/apd.296339



MLA (The Modern Language Association) Style

Kutlu, Ayse, and Nagihan Cevher Binici. "Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?." doi:10.5455/apd.296339



APA (American Psychological Association) Style

Kutlu, A. & Binici, N. C. (0) Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. doi:10.5455/apd.296339





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