ISSN 1302-6631
 

Review Article 


The Use of Cytochrome P450 Phenotyping in Psychiatry

Gökben Hızlı Sayar, Gül Eryılmaz, Eylem Özten, Işıl Göğcegöz Gül, Mehmet Emin Ceylan.

Abstract
Individualization of pharmacotherapy is essential in order to optimize efficacy and minimize toxicity, especially for compounds with narrow therapeutic index. Cytochrome P450 phenotyping has been a valuable research tool and a way of assessing the genetic basis of metabolic capacity. Technique depends on estimating metabolic capacity based on conclusions drawn from another probe drug. Phenotyping allows estimation of the total influence of drug interactions, genetic polymorphisms, hepatic diseases and other factors altering pharmacokinetics. This requires the use of selective substrates for specific cytochrome enzymes. Recently some phenotyping methods are becoming widely used especially for the in vivo evaluation of multiple cytochrome enzymes by using probe cocktails.

Key words: cytochrome P450, phenotyping, probe drugs



Psikiyatride Sitokrom P450 Fenotiplemesi Kullanımı

Ozet
Özellikle tedavisel aralığı dar olan ilaçlar için tedavi etkinliğini sağlayabilmek, yan etkileri en aza indirebilmek için farmakolojik tedavinin kişiye özel uygulanması gereklidir. Sitokrom P450 enzimlerinin fenotiplemesi hem değerli bir araştırma yöntemi hem de metabolik kapasitesinin genetik temelinin değerlendirilmesi için bir araçtır. Teknik, bir prob ilaç (ölçüm maddesi) kullanarak metabolik kapasitenin tahmin edilmesine dayanır. Fenotipleme ilaç etkileşimleri, genetik polimorfizmler, hepatik hastalıklar ve ilacın farmakokinetiğini etkileyebilecek diğer faktörlerin toplam etkisini gösterir. Bunun için fenotiplemede her bir sitokrom enzim sistemine özgü substratların kullanımı gereklidir. Son dönemde birden fazla sitokrom enzim sisteminin in vivo değerlendirmesine olanak tanıyan ölçüm maddeleri kokteylleri ile fenotipleme kullanılmaya başlanmıştır.

Anahtar Kelimeler: fenotipleme, prob ilaçlar, sitokrom P450


 
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How to Cite this Article
Pubmed Style

Sayar GH, Eryilmaz G, Ozten E, Gul IG, Ceylan ME. [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anadolu Psikiyatri Derg. 2014; 15(4): 358-364. Turkish. doi:10.5455/apd.42867


Web Style

Sayar GH, Eryilmaz G, Ozten E, Gul IG, Ceylan ME. [The Use of Cytochrome P450 Phenotyping in Psychiatry]. http://www.anadolupsikiyatri.net/?mno=42867 [Access: September 21, 2018]. Turkish. doi:10.5455/apd.42867


AMA (American Medical Association) Style

Sayar GH, Eryilmaz G, Ozten E, Gul IG, Ceylan ME. [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anadolu Psikiyatri Derg. 2014; 15(4): 358-364. Turkish. doi:10.5455/apd.42867



Vancouver/ICMJE Style

Sayar GH, Eryilmaz G, Ozten E, Gul IG, Ceylan ME. [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anadolu Psikiyatri Derg. (2014), [cited September 21, 2018]; 15(4): 358-364. Turkish. doi:10.5455/apd.42867



Harvard Style

Sayar, G. H., Eryilmaz, G., Ozten, E., Gul, I. G. & Ceylan, M. E. (2014) [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anadolu Psikiyatri Derg, 15 (4), 358-364. Turkish. doi:10.5455/apd.42867



Turabian Style

Sayar, Gokben Hizli, Gul Eryilmaz, Eylem Ozten, Isil Gogcegoz Gul, and Mehmet Emin Ceylan. 2014. [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anatolian Journal of Psychiatry, 15 (4), 358-364. Turkish. doi:10.5455/apd.42867



Chicago Style

Sayar, Gokben Hizli, Gul Eryilmaz, Eylem Ozten, Isil Gogcegoz Gul, and Mehmet Emin Ceylan. "[The Use of Cytochrome P450 Phenotyping in Psychiatry]." Anatolian Journal of Psychiatry 15 (2014), 358-364. Turkish. doi:10.5455/apd.42867



MLA (The Modern Language Association) Style

Sayar, Gokben Hizli, Gul Eryilmaz, Eylem Ozten, Isil Gogcegoz Gul, and Mehmet Emin Ceylan. "[The Use of Cytochrome P450 Phenotyping in Psychiatry]." Anatolian Journal of Psychiatry 15.4 (2014), 358-364. Print.Turkish. doi:10.5455/apd.42867



APA (American Psychological Association) Style

Sayar, G. H., Eryilmaz, G., Ozten, E., Gul, I. G. & Ceylan, M. E. (2014) [The Use of Cytochrome P450 Phenotyping in Psychiatry]. Anatolian Journal of Psychiatry, 15 (4), 358-364. Turkish. doi:10.5455/apd.42867





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